An argument is that CXCR1 is redundant; however the importance of CXCR1 was highlighted by studies suggesting that CXCR1 plays a significant role on the regulation and progression of chronic inflammatory disorders, including cystic fibrosis, COPD, and in sporadic urinary infections [6], [7]. The gene discussed is CXCR1; the disease is chronic obstructive pulmonary disease.