UBE3A and Anxiety: To ensure that the motor coordination defect in the AS TR2-UBE3A mice was not the result of altered activity or anxiety, an open field (Fig. 3B ANOVA Tukey [F(2,27) = 0.07563, P>0.05)]) and elevated plus maze test (Fig. 3C ANOVA Tukey [F(2,27) = 0.5290, P>0.05] and Fig. 3D ANOVA Tukey [F(2,27) = 2.472, P>0.05]) were performed and showed no changes in AS TR2-UBE3A versus AS TR2-GFP mice.