FOXC2 and Lymphedema - distichiasis: FoxC2 is also expressed in lymphatic endothelial cells during development [32, 33], and mutations in human FoxC2 are responsible for the autosomal dominant syndrome lymphedema distichiasis, which is characterized by the obstruction of lymph drainage in the limbs and by the growth of an extra set of eyelashes [34, 35].