The precise role of PDGF signaling in tumor angiogenesis remains a subject of debate [54]; however, PDGF mediates the maturation and stabilization of blood vessels during normal vessel growth by regulating the interaction between endothelial cells and mural cells (e.g., vascular smooth muscle cells and pericytes) that are loosely associated with the tumor endothelium, and PDGF-B inhibition is associated with both the loss of mural cells and tumor-vessel regression [55]. Here, PDGFB is linked to neoplasm.