The blockade of both VEGF and PDGF receptor-β signaling in tumor blood vessels with kinase inhibitors also induces tumor vessel regression [56, 57], and paracrine signaling between pericytes and the tumor endothelium [58] could increase the instability of the tumor vessels of FoxC2+/– mice by reducing VEGF and PDGF-B signaling [15]. The gene discussed is FOXC2; the disease is neoplasm.