FOXC2 and neoplasm: Furthermore, FoxC2 expression is induced by hypoxia after ischemia/reperfusion injury in the kidney [47], and the hypoxic gradient that develops in the tumor microenvironment increases SDF-1 expression in CAFs and CXCR4 expression in tumor cells [48, 49]; thus, FoxC2 could also contribute to tumor angiogenesis through a hypoxia-related mechanism.