CDH5 and neoplasm: Recent studies have shown that the activity of FoxC2 and the Ets transcription factor Etv2 combine to regulate endothelial-specific gene expression during early development, including Flk1, Tie2, and VE-cadherin [27], and the Ets transcription factors are known to be important for tumor angiogenesis [28], but whether FoxC2 and Etv2 also coregulate tumor vessel formation has yet to be determined.