CD40 and rheumatoid arthritis: The CD40 gene, which was reported as significant in GWAS of MS and RA [28], showed evidence for association at several variants in linkage disequilibrium (LD) (r2>0.70), the most significant being rs6074022 (P = 1.41×10−03, PFDR = 1.24×10−02) (Table 2), upstream of CD40. The risk allele for this variant is the same in SLE as the one reported in MS.