There are however many examples of virus infection leading to the induction of host genes classically defined as interferon stimulated genes (ISGs) in the absence of interferon and/or STAT1 mediated signalling; examples include LCMV [61] where the induction of ISG-49, ISG-54, and ISG-56 was observed in the absence of STAT1, and also HSV-1 which elicits an IRF3-dependent, but IFN-independent cellular antiviral response [62]–[64]. This evidence concerns the gene IFIT1 and viral infectious disease.