CASP3 and breast cancer: In three independent experiments, transfection of a cocktail of 2′OMe oligonucleotides against miR-K12-1, K12-3 and K12-4-3p (2′OMe-miR-K12-1/3/4) in BC-3 cells resulted in a modest but measurable increase of Casp3 protein level compared to a control 2′OMe oligonucleotide (2′OMe-miR-67) (1.4-fold on average, p = 0.0486) (Figure 7E).