TP53 and neoplasm: Among those, tumor promoting factors like DNA methyltransferase (DNMT), epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), insulin-like growth factor 1 receptor (IGF1R), matrix metalloproteinase (MMP), vascular endothelial growth factor A (VEGFA) and BCL-2 are down-regulated by EGCG while tumor suppressor p53 is up-regulated [11].