TP53 and neoplasm: IARC TP53 database (version R14, November 2009) [10] shows that human p53N239S (or p.N239S) has been reported as a somatic mutation in 32 tumor cases, tumor origin tissues including breast, colon, stomach, hematopoietic and reticuloendothelial systems, liver and intrahepatic bile ducts, bronchus and lung, and brain.