At present, some tumor-associated genes have been identified near these loci, such as FHIT (3p), RASSF1A (3p), APC (5q), ANXI (9q), DEC1 (9q), RB1 (13q), BRCA2 (13q), ING1 (13q), and TP53 (17p). This evidence concerns the gene RB1 and neoplasm.