The involvement of α1,2-fucosyltransferase in drug-resistance toward 5-FU has also been reported in mice treated with 5-FU and human colon carcinoma-derived cells with 5-FU-resistance, but H-2 and Leb antigens were utilized as the drug-resistance-related glycoconjugates synthesized by α1,2-fucosyltransferase [17]. This evidence concerns the gene MUC5AC and colon carcinoma.