Clinicians should consider a diagnosis of analbuminemia even when the clinical laboratory detects ALB levels higher than 10 g/L, because routine assays, based on dye binding techniques, suffer from very poor accuracy in presence of a low ALB amount, and also immunoassays and serum protein electrophoresis may reveal non-zero amounts of the protein. The gene discussed is ALB; the disease is congenital analbuminemia.