GNRHR and colorectal carcinoma: GnRHR is known to transmit signals via beta-catenin (Salisbury et al, 2008; Gardner and Pawson, 2009), the key signalling molecule of the canonical Wnt pathway (Gordon and Nusse, 2006), whereas growth factors and inflammatory factors have been suggested to activate the Wnt pathway in CRC to stimulate the mobility of tumour cells (DeNardo et al, 2008).