The TNF-α, IL-1β, IL-6, IL-8 and IL-10 levels were significantly increased in group II when compared with group I. However, administration of Ginkgo leaf parenteral solution for 15 days dose-dependently significantly decreased the TNF-α, IL-1β, IL-6, IL-8 and enhanced IL-10 levels in cochlea of Group III and IV rats when compared with the OM model group (II). This evidence concerns the gene IL1B and ocular melanoma.