HIF1A and nonpapillary renal cell carcinoma: Although one report examined the effects of HDAC inhibition upon HIF-1 expression in CCRCC cells [50] and another utilized LBH589 in combination with rapamycin [15], an analysis of these agents upon HIF-2 expression or activity is lacking, an important oversight given that a majority of CCRCC tumors preferentially express HIF-2 [4].