These findings not only reaffirm our earlier results and those reported by Duan et al. [40] on metformin-induced activation of the ATM/AMPKα pathway, but they additionally suggest that metformin-mimicked glucose restriction appears to reactivate the senescence program in cancer cells (Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Vellon L, Menendez JA. The gene discussed is ATM; the disease is cancer.