STK11 and Peutz-Jeghers syndrome: Taken together, these data suggest that the novel STK11 mutation, c.904C > T (p.Q302X), which was found in two unrelated Chinese PJS families, causes partial loss of the kinase domain and complete loss of the C-terminal domain, and may contribute to polyp formation and tumorgenesis through various mechanisms, such as loss of growth arrest, apoptosis, and loss of cell polarity.