HNF4A and neoplasm: In addition, expression of the β-catenin/TCF/LEF transcription complex-regulated genes c-Myc and COX-2 were reduced in tumor cells upon treatment with the PKA antagonist Rp-8-Br-cAMPS as evident from the median number of nuclei positive for c-Myc (reduced from 60% in control to 20%; P < 0.001, Figure 3A, B and Additional file 3, Figure S2) and from the cytoplasmic expression levels of the COX-2 enzyme (reduced from 136 in control to 106 median inverse grayscale intensity units in the treated group; P < 0.001, Figure 3A, B and Additional file 3, Figure S2).