MYC and colon carcinoma: While treatment of HCT 116 colon carcinoma cells with PGE2 for 30 min (phosphorylated β-catenin) or 1 h (c-Myc) increased phosphorylation of both Ser552 and Ser675 as well as c-Myc levels, treatment with indomethacin or Rp-8-Br-cAMPS reduced levels compared to untreated sample.