SEPTIN9 and adenoma: Although tissue studies showed that adenomas have elevated levels of methylated SEPT9 DNA comparable to CRCs (data not shown), the adenoma detection rate in the plasma was a modest 10% to 12%, consistent with previous studies of the SEPT9 biomarker [7,10] and similar to that reported for a standard guaiac fecal occult blood test (FOBT) [13].