A marked decrease in adiponectin mRNA levels (P < 0.001) was measured in white adipose tissue of VD male (0.54) and female (4.53) groups and AD male (0.61) and female (2.84) groups compared to control (1.24 for males and 15.67 for females) (Figure 4.A). This evidence concerns the gene ADIPOQ and Alzheimer disease.