IL2 and melanoma: Additionally, the observed immunotherapy-like mixed responses (e.g. Figure 1B) and partial but durable responses (e.g. Figure 2) coupled to the known lack of cytotoxicity of DAB/IL2 to human melanoma cells implies that the clinical activity of DAB/IL2 may rely in part on the known Treg-depleting effects of DAB/IL2 [19].