After four cycles of DAB/IL2, he experienced the complete regression of his hepatic metastases confirmed by FDG-PET imaging and resolution of his symptoms but only a modest reduction in his duodenal mass (compare Baseline to +4 Months, Figure 1A; the increased 18 F-FDG uptake in the left kidney is due to hydronephrosis which is unrelated to melanoma). The gene discussed is IL2; the disease is hydronephrosis.