IgE-mediated drug allergy(urticaria, angioedema, anaphylaxis, bronchospasm):• Carcinoid syndrome• Insect bites/stings• Mastocytosis• Asthma• Food allergy• Scombroid fish poisoning• Latex allergy• Infection (EBV, hepatitis A, B, C, gastrointestinal parasites). Here, IGHE is linked to mastocytosis.