Most importantly, having the potential to upregulate the expression of specifics matrix metalloproteinases (MMPs) such as MMP-1, MMP-3, MMP-9, MMP-13, IL-17A, and IL-17F have been shown to be tissue-damaging cytokines and are intimately involved in autoimmune diseases, for example, Crohn's disease [25, 26], EAE [4], collagen-induced arthritis (CIA) [5], Sjögren's syndrome (SjS) [27, 28] and SLE which will be later discussed [29–34]. Here, IL17A is linked to systemic lupus erythematosus.