AGT and cardiac hypertrophy: Cardiac hypertrophy as indexed by the ratio of the heart weight to body weight was significantly increased in mice infused with Ang II as compared to control and IRMI QC-13-infused mice averaging 5.8 ± 0.3, versus 4.8 ± 0.2, versus 5 ± 0.2 mg/g in each group, respectively (Figure 1(b)).