Such an interpretation is indeed supported by the fact that most genes whose mutations are associated with cancer (e.g. ABL1, BRCA1, SRC, ATM, BRAF, PTEN, TGFBR2, EGFR, RB, p53, SMAD4 etc) in fact belong to the category of RHS described here. The gene discussed is TGFBR2; the disease is cancer.