A number of anticancer therapies, including DNA-damaging chemotherapeutic drugs, have been observed to induce the accumulation of autophagosomes in tumor cell lines and inhibition of autophagy by pharmacologic inhibitor or genetic knockdown of phylogenetically conserved autophagy-related genes, such as Atg5 and Atg7, usually enhanced drug-induced cytotoxicities [12]. This evidence concerns the gene ATG5 and neoplasm.