In fact, previous reports showed how this signaling pathway is implicated in cDDP resistance [12] and how it is connected to molecules critical in tumor growth and the response to cDDP, such as p53 or c-Abl [13], [14] and more recently with the epidermal growth factor receptor (EGFR), which has indeed become a new target in lung cancer therapy [15], [16]. This evidence concerns the gene EGFR and lung cancer.