Remarkably, as observed for NSCLC derived cell lines, resistant cell lines (HN12 and HN26) exhibit low levels of MKK6 and high levels of MKK3, while sensitive cell lines (HN19 and HN30) display high levels of MKK6 and low levels of MKK3 (Fig 6C). The gene discussed is MAP2K6; the disease is non-small cell lung carcinoma.