Fig. 2 shows the morphology of the original tumors (G0) of primary colon carcinoma with lymphatic and hepatic metastases and their third generation (G3) implants in nude mice. There were no significant morphological differences between the tumor resected from the patient and the initial successful implants. The explanted tumor pieces also showed similar VEGF and EGFR expressions compared to the corresponding original tumors (Fig. 3,4). This evidence concerns the gene EGFR and neoplasm.