Furthermore, four different metastatic melanoma cell lines tested (WM852, WM164, WM165 and WM239) as well as the Bowes, G361 and WM793 cells derived from non-metastatic primary melanoma all expressed MT1-MMP, whereas MT3-MMP was expressed in three cell lines originally isolated from metastatic melanomas (WM852, WM165 and WM239) and WM793 cell line isolated from advanced primary melanoma (Fig. 1C). Here, MT3 is linked to metastatic melanoma.