In addition to mutations detected in the genes routinely tested for arRP, we identified two mutations (p.T342M and p.S297R) typically associated with autosomal dominant cases of RP (adRP) in the rhodopsine gene, Rho. This evidenced that Rho not only plays an important role in the pathogenesis of adRP, but it is also involved in a number of arRP cases and its routine analysis in those families should be considered. Here, RHO is linked to retinitis pigmentosa 1.