IL6 and arthritic joint disease: Some research has shown that Annexin A1 can inhibit inflammatory response [29]–[32]: arthritis has been found in Annexin A1-knockout mice, accompanied by increased expression of IL-1 and IL-6, and leukocyte and IL-1β migration was significantly inhibited also in Annexin A1-knockout mouse models of inflammation, suggesting that Annexin A1 is closely related to inflammatory response.