Figure 1B shows that, when excluding the variant with the strongest risk effect (HLA-DRB) from the risk score, individuals with 0 to 5 risk alleles have a decreased risk of 0.50 (95% CI 0.34–0.73) and individuals with 8 to 10 risk alleles have an increased risk of 1.33 (95% CI 1.07–1.64) in comparison with the a priori risk for developing MS. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.