On the other hand, under high insulin concentrations (such as following prandial insulin administration), hypoglycemia is the result of both hepatic suppression and the increase of peripheral uptake of glucose by fat and muscle (GU): this scenario is more complex (the so called ‘push-pull phenomenon’) and glucose concentration may fall in ISF sooner than in plasma [23,26,28]. This evidence concerns the gene INS and Hypoglycemia.