These mice include two Tg mouse models of Alzheimer's disease (AD); Tg(MoDpl)/Prnp0/0 mice that show cerebellar degeneration as a result of Dpl expression [38]; a Tg mouse model of Parkinson's disease; and a Tg mouse model of frontotemporal dementia. The gene discussed is PRND; the disease is early-onset autosomal dominant Alzheimer disease.