SOD2 and prostate cancer: Our laboratory used antibodies specific to oxidative damage products to analyze differences in redox state in subcellular organelles in comparisons of normal human prostate, primary prostate cancer, and metastatic prostate cancer tissues, and found that levels of mitochondrial MnSOD protein and nuclear levels of the oxidative damage products 8-hydroxy-2′-deoxyguanosine (8OHdG), 4-hydroxy-2-nonenal protein adducts, and 3-nitrotyrosine were greater in metastasic cancers compared to primary human prostate cancers [18].