TGFB1 and neoplasm: Interestingly, two regulators of RGC-32, TGF-β and RUNX1 also appear to promote or repress tumourigenesis depending on the cell context, developmental stage or tumour stage (for reviews see [58] and [59]) and it is possible that some of the downstream effects of these factors may be mediated through regulation of RGC-32 expression.