A non-synonymous variant at codon 23 of the KCNJ11 gene, which causes a glutamic acid to lysine (E23K; rs5219) substitution at the N-terminal, has been shown to be associated with T2DM across various ethnic groups [3], [4], including Chinese[5], [6], in cross-sectional studies. This evidence concerns the gene KCNJ11 and type 2 diabetes mellitus.