Finally, the Cox regression analysis was performed for glycaemic progression (NGT at baseline -> IGT/IFG/T2DM by CRISPS2 or CRISP3; and IGT/IFG at baseline -> T2DM by CRISP2 or CRISPS3) which involved both incident prediabetes and incident T2DM case subjects. The gene discussed is CRISP3; the disease is type 2 diabetes mellitus.