SYK and neoplasm: While researchers have been isolating, and also wrongly re-isolating [2], transplantable T cell lymphoma lines since the 1940s from mice after chemical tumor induction/promotion [3], only recently the ectopic expression of an inducible T cell kinase (ITK)-spleen tyrosine kinase (SYK) fusion gene has allowed to establish the first mouse model of PTCL [1], [4], [5].