Anti-CRD4 MR scFv #G11 preserved CD206low macrophage phenotype during co-culture with tumor cells, as shown by the up-regulation of IL-12 (Fig. 5D,I, condition 4), TNF-α (Fig. 5E,J, conditions 4,6), and IL-6 (Fig. 5F,K, conditions 4,6). The gene discussed is TNF; the disease is neoplasm.