Therefore, the present study aims to evaluate: (a) the effect of CBD on enteroglial-derived S100B protein expression in a mouse model of acute intestinal inflammation and in rectal biopsies derived from patients with ulcerative colitis; (b) the efficacy of CBD to prevent S100B-mediated amplification of inflammatory/immune response through the involvement of other immune cells such as macrophages and mast cells; (c) the anti-apoptotic effect of CBD in course of inflammation. Here, S100B is linked to ulcerative colitis.