In summary, we report higher incidence of concomitant anti-tubercular and efavirenz based ARV DILI among Ethiopian TB-HIV co-infected patient The identified predictors include; slow acetylation status, CYP2B6*6/*6 and ABCB13435TT genotype, elevated baseline liver aminotransferases, high plasma efavirenz concentration, lower hemoglobin and albumin levels. The gene discussed is CYP2B6; the disease is tuberculosis.