Similar increase in transcript levels of these genes were also observed in another lung cancer cell line, A549 (Fig. 3c) where we observed 1.6 fold (p value  =  0.03) increase in HMGCR levels, 1.4 fold increase in HMGCS1, 1.56 fold increase in IDI1, 2.4 fold increase in CYP27B1, and 1.25 fold increase in INSIG1 levels at 48 h post transfection of A549 cells with STAT6 specific siRNA in comparison to the untransfected A549 cells. This evidence concerns the gene CYP27B1 and lung cancer.