Upregulated mucosal expression of numerous chemokines and their counter receptors including CXCL8 (IL-8)/CXCR2, CXCL9,10,11/CXCR3, CCL25/CCR9, CCL19,21/CCR7, and CCL20/CCR6 is evident in active IBD and in models of colitis [78–80]. The gene discussed is CXCL8; the disease is colitis.