Therefore, immunogenic tumor cell death mediated by chemotherapeutics like oxaliplatin is a multistep process characterized by a temporal sequence of events (Figure 2) including early translocation of calreticulin to the cell surface, and thereafter interaction of CRT with multiple receptors on DC with apoptotic bodies phagocytosis, release and exposure of heat shock proteins, and late release of HMGB1 (60). The gene discussed is HMGB1; the disease is neoplasm.