In our study, we also found that FoxO1 and/or FoxO3A nuclear translocation is concomitant with cell apoptosis induced by Mirk knockdown, which together with previous studies (24,25) suggest that it might be the subcellular localization and phosphorylation of FoxO that is altered in Mirk siRNA-treated ovarian cancer cells. This evidence concerns the gene FOXO1 and ovarian carcinoma.