Previous studies also demonstrate Dyrk1A, the closest isoform of Mirk may phosphorylate FoxO1 and promote nuclear output (20,21), thus there is a possibility that it is the subcellular localization and phosphorylation of FoxO factors but not the total protein level that is altered in Mirk/Dyrk1B siRNA-treated ovarian cancer cells. The gene discussed is DYRK1A; the disease is ovarian cancer.