CASP3 and ovarian carcinoma: To further determine the effects of FoxO factors on Mirk-modulated ovarian cancer cell survival, FoxO siRNAs were exposed to the cells of OV2008, OVCAR5 or OVCAR8 treated with/without Mirk siRNA for 72 h, then the apoptotic cells evidenced by cleaved caspase-3 were detected by flow cytometry analysis.