Preclinical study of human gastric cancer cell lines has demonstrated the anti-proliferative effect of PI3K inhibition by LY294002 or mTOR inhibition by everolimus and evidenced the synergistic efficacy with 5-fluorouracil or sunitinib, indicating a role for the PI3K/AKT pathway in gastric cancer carcinogenesis (10–12). Here, MTOR is linked to gastric cancer.