In total, twenty-two of the frequently altered genes (ABL1, AXIN2, CCND1, COL4A2, DAPK3, EGFR, EPAS1, FLT3, GLI2, HDAC2, IKBKB, JUP, LAMA1, MSH6, PRKCB, PTEN, RUNX1T1, WNT10B, WNT2, WNT3, WNT3A, WNT6) belong to the pathways in cancer KEGG map (hsa05200). This evidence concerns the gene MSH6 and cancer.