It has been found that PRC-target genes, including the Hox gene clusters, are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets (47) and that methylation on Lys27 of histone H3, a modification mediated by the Polycomb repressor complex 2 (PRC2), pre-marks genes for de novo methylation in cancer (46). Here, PPRC1 is linked to cancer.