A significant number of the hypermethylated genes encode transcriptional factors and chromatin remodelers (KLF7, SLC2A4RG, TBX2, IRX2, GLI2, SOX8, YBX1, GABPB1, HDAC2, SIX1, RFX1, MKX, FOXD2, RUNX2, TLX2, TLX1), some already reported to be associated to colon cancer (49–51). The gene discussed is TLX2; the disease is malignant colon neoplasm.