In total, twenty-two of the frequently altered genes (ABL1, AXIN2, CCND1, COL4A2, DAPK3, EGFR, EPAS1, FLT3, GLI2, HDAC2, IKBKB, JUP, LAMA1, MSH6, PRKCB, PTEN, RUNX1T1, WNT10B, WNT2, WNT3, WNT3A, WNT6) belong to the pathways in cancer KEGG map (hsa05200). The gene discussed is LAMA1; the disease is cancer.