In total, twenty-two of the frequently altered genes (ABL1, AXIN2, CCND1, COL4A2, DAPK3, EGFR, EPAS1, FLT3, GLI2, HDAC2, IKBKB, JUP, LAMA1, MSH6, PRKCB, PTEN, RUNX1T1, WNT10B, WNT2, WNT3, WNT3A, WNT6) belong to the pathways in cancer KEGG map (hsa05200). Here, PTEN is linked to cancer.