TBX2 and malignant colon neoplasm: A significant number of the hypermethylated genes encode transcriptional factors and chromatin remodelers (KLF7, SLC2A4RG, TBX2, IRX2, GLI2, SOX8, YBX1, GABPB1, HDAC2, SIX1, RFX1, MKX, FOXD2, RUNX2, TLX2, TLX1), some already reported to be associated to colon cancer (49–51).