Besides that elevated MMP-7 expression seems to correlate with the metastatic potential of colon cancer, it should be noted that the capability of this MMP to locally increase the IGF-1/2 bioavailability by cleavage of IGF-1 binding protein(s) (32) might contribute to increased proliferation/survival and metastatic potential of the malignant cells. This evidence concerns the gene IGF1 and colonic neoplasm.