VEGFA and central nervous system cancer: To understand the molecular mechanisms by which miRNA-205 inhibited glioma cells growth and invasion, we searched for putative miRNA-205 targets as predicted by the commonly cited programs such as TargetScan, miRanda and PicTar and found 3′UTR of VEGF-A containing the highly conserved putative miRNA-205 binding sites (Fig. 5A).