Recently, using an exome sequencing-based approach, 2 independent groups have identified a missense mutation in vacuolar protein sorting 35 homolog (VPS35 c.1858G>A; p.Asp620Asn) as the probable cause of late-onset PD in a number of kindreds (Vilariño-Güell et al., 2011; Zimprich et al., 2011). The gene discussed is VPS35; the disease is Parkinson disease.