采用PCR-RFLP方法检测130例以含铂方案化疗的晚期NSCLC患者外周血DNA中XRCC1 Arg194 Trp、Arg399 Gln和XRCC3 Thr241 Met基因多态性, 分析其基因型与化疗疗效的关系。. The gene discussed is XRCC1; the disease is non-small cell lung carcinoma.