BIRC5 and cancer: Survivin is a member of the inhibitor of apoptosis family of proteins.The Survivin protein is highly expressed in most human tumors, but it is completely absent in terminally differentiated cells.Consequently, Survivin is an ideal target for cancer therapy because cancer cells are targeted and normal cells are left alone.The aim of this study is to construct a lentivirus-shRNA vector, and to disrupt the expression of Survivin in A549 cells.The effect of sh-RNA Survivin on A549 cells was analyzed.